The application of platform analytical methods to support testing of early phase biologics enables expedited paths to IND by removing analytical method development from critical path. Structural conservation within commonly investigated immunoglobulin subclasses allows for the approach to be de-risked when a platform method has been previously validated with a standard of sufficient similarity to the molecule under test. Structural variability of small molecule linker payloads and their impact on the physicochemical properties of the protein intermediate post conjugation, necessitates a more involved strategic approach to enable use of platform methods for antibody drug conjugates (ADCs).
This webinar will cover lessons learned from the application of platform analytical methods to IgGs and discuss the potential to apply platform strategies to ADCs and beyond.
The expert speaker will discuss the following:
• The importance of Platform Analytical Strategies
• Justification of application of Platform Analytical Strategies to IgGs
• Challenges with Application of Platform Analytical Strategies to ADCs
• Lessons Learned from IgGs and Application of Platform Strategies to ADCs
Register for this webinar to learn how the application of Platform Analytical Strategies could expedite your pathway to IND for ADCs and beyond.
Key Learning Objectives
- Understand the importance of Platform Analytical Strategies
- How Platform Analytical Strategies can help expedite paths to IND
- Key lessons learnt from IgGs and Application of Platform Strategies to ADCs
