Purification of adeno-associated viruses (AAV) is a rate-limiting step of therapeutic development, impacting the cost, safety, and efficacy of the final product. Traditional separation processes - filtration accompanied by affinity capture - are the industry standard for primary contamination clearance but are inefficient, costly, and impractical when applied to gene therapy viral vectors.
These deficiencies are often overlooked in this area of gene therapy, where clinical demonstration of candidate is prized over process intensification. Before you know it, an inefficient bench-scale process is scaled up for full manufacturing, and those high costs of manufacturing are now under new scrutiny. Ideally, a highly productive manufacturing process can be implemented more simply, from discovery to full manufacturing, with less development time at each step.
To address inefficiencies present in traditional separation processes, Isolere Bio by Donaldson has developed IsoTag™ AAV – a scalable chromatography-free purification solution. This specialized reagent facilitates an AAV purification process that combines filtration and affinity separation into a single processing step via the novel mechanism of liquid-liquid phase transition.
Join this live webinar and learn how this robust technology differs from other offerings. Discover how IsoTag™ AAV can speed up your AAV purification processes while producing high-quality yields that can be maintained during operational scale-up. Learn how you can easily implement this technology with commercially available tangential-flow filtration equipment that can be scaled linearly – enabling the acceleration of time-to-clinic.
Register now and uncover how IsoTag™ AAV can help you accelerate your research and reduce deficiencies associated with scaling your therapeutic development operation!
Key Learning Objectives:
- Understand how bottlenecks in traditional processes of purifying AAVs can be solved with new technologies.
- Learn how to implement a cost-effective bench-scale AAV purification that can be adapted for full-scale manufacturing.
- Learn the advantages of implementing a chromatography-free AAV purification process.
- Discover how affinity phase separation technology achieves higher purity and yield of AAV.
