Timed interval cerebrospinal fluid sampling by indwelling catheterization is a valuable tool for pharmacokinetic and pharmacodynamic assessment of drugs. Unlike a single lumbar puncture (‘spinal tap’) this procedure provides information on the time response relationship.
This will reveal information on blood brain passage of the drug as well as changes in drug related biomarkers e.g. Alzheimer's disease-sensitive biomarkers. cCSF is an invasive procedure that requires solid medical expertise in order to execute properly and safely. Together with the University Medical Center Groningen, QPS has developed a standardized research tool that is regularly applied in clinic trials at the QPS clinic in Groningen, The Netherlands.
In this webinar we will share information on the technology used, best practices and potential pitfalls, when using this technique. A Board-certified anaesthesiologist always performs CSF catheterization. Professor Absalom will share the “dos and don’ts” based on his extensive experience with this procedure. Also, the most common side effects will be discussed.
We will present an overview of 4 case studies that show the different applications of the use of cCSF in clinical research. We will discuss the different clinical designs of each of these studies, and how these designs can be applied to and implemented in a SAD or MAD study design. We will also discuss the difference between cCSF and single punctures.
Key Learning Objectives
- Learn about the technology used for cCSF, as well as the potential pitfalls when using this technique.
- Learn the critical factors of cCSF by indwelling catheterization, based on the extensive experience of a Board-certified anaesthesiologist who regularly performs this procedure.
- Learn about the most common side effects of cCSF procedures.
- Understand the various uses of cCSF in early phase clinical research
Target Audience
- CEO
- Chief of Research
- Head
- VP
- Directors of Clinical Research
- Drug Development
- Clinical Trials
- Clinical Research Services
- Clinical Operations
- Clinical Data Management
