There are many reasons to work on popular drug targets. Despite prolific targeting and the increased challenge of finding new ways to exploit them, established targets still represent a tried and tested route to tackle specific diseases. With a wealth of documented literature, popular targets can also represent a drug discovery pathway with fewer unknowns, making them attractive in a commercial environment where the appetite for risk is low. However, how can you discover distinct opportunities within well-trodden chemical ground?
Fragments represent a powerful method for finding effective new binding sites on established targets. However, fragments are not a universal solution. You will learn how to assess the potential value that fragment-based discovery could contribute to your research, and review how fragment screening can be leveraged to quickly uncover unexplored ligandable sites.
Delving into the detail, we will also explore the impact of predefining the mode of action (MoA) on successfully achieving screening objectives, and briefly cover options for progressing promising hits rapidly. Each key area of the webinar will include illustrative data and case study examples highlighting where and how these techniques have been applied to existing drug discovery research.
Attend this webinar to expand and update your fragment-based drug discovery knowledge, and learn from recent examples of how fragments are being used to uncover novel opportunities for popular targets.
Key Learning Objectives
- Learn how to evaluate whether fragments are a viable option for investigating your chosen drug target.
- Explore the impact of predefining the MoA when designing a fragment campaign.
- Understand how fragments can be used to effectively explore the chemical space around popular targets to identify new ligandable sites.
- Review how to use readily available analogs to rapidly progress promising fragment hits.
