Subcutaneous models are widely used for the evaluation of new drug candidates. However, they lack the native tumor microenvironment, leading to limited reproducibility of the complexity of human cancers. To address this, orthotopic models have emerged as an alternative, enabling evaluation of tumor progression, invasion, and therapeutic response in a setting closer to clinical reality. Supported by advanced imaging methods such as MRI, they open the way to more translationable preclinical studies.
In this webinar, our experts will introduce the principles and advantages of orthotopic models in oncology research, highlighting how they better capture the biology of human tumors with the assistance of imaging. We will demonstrate how MRI allows non-invasive, longitudinal monitoring of orthotopic tumor growth and treatment response, offering unique insights that cannot be achieved by conventional methods.
Through practical case studies, we will demonstrate how the integration of MRI imaging in your preclinical studies make orthotopic models powerful tools for your drug development programs, while abiding to the 3Rs rule.
Key Learning Objectives
- Discover the added value of orthotopic models compared to subcutaneous
- How to use MRI in the development of your orthotopic model
- A typical workflow for preclinical studies
Join us to discover how this powerful combination can improve the predictivity of your oncology programs and accelerate the path from preclinical research to clinical impact.
