Most people with drug-resistant tuberculosis (DR-TB) are never appropriately treated. This is primarily due to gaps in the diagnostic care cascade. This talk will summarise the landscape of drug-resistant tuberculosis in Africa and key challenges and opportunities for the molecular diagnosis of resistance to innovative new regimens. It will focus on the drug-resistant tuberculosis test pipeline and especially the promising LiquidArray® technology, including its application for XDR-TB detection and the underlying technology and implementation considerations required to maximize impact. Future research questions and lessons to be learnt from prior drug-resistant tuberculosis diagnostic technologies will be highlighted.
Key Learning Objectives:
- Understand the landscape of DR-TB and diagnostic gaps.
- Understand the upcoming DR-TB pipeline and their strengths and limitations in the light of World Health Organization guidance.
- Understand the multiplexing LiquidArray® technology and its applications for XDR-TB detection.
- Future research directions.
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